Библиография

1. 1. Александрова Н.П. Ожирение как основной фактор влияния метаболического синдрома на функцию внешнего дыхания // Успехи физиол. наук. 2024. Т. 55. № 4. С. 113–124. https://doi.org/10.31857/S030117982404006
2. 2. Лобов Г.И. Сократительная функция брыжеечных лимфатических узлов крыс при ожирении // Вопросы питания. 2024. Т. 93. № 4 (554). С. 39–48. https://doi.org/10.33029/0042-8833-2024-93-4-39-48
3. 3. Панькова М.Н. Дисфункциональные изменения брыжеечных артерий в ранние сроки ожирения крыс при высокожировой диете // Ожирение и метаболизм. 2022. Т. 19. № 2. С. 158–165. https://doi.org/10.14341/omet12842
4. 4. Панькова М.Н. Эндотелий-независимое антисократительное влияние периваскулярной жировой ткани аорты крысы в норме и при метаболических нарушениях, индуцированных диетой кафе // Росс. физиологический журнал им. И.М. Сеченова. 2023. Т. 109. № 12. С. 1870–1872. https://doi.org/10.31857/S0869813923120075
5. 5. Панькова М.Н. Возврат к стандартному питанию после высококалорийной диеты улучшает метаболические показатели и реактивность аорты крысы // Ожирение и метаболизм. 2024. Т. 21. № 4. С. 416–423. https://doi.org/10.14341/omet13105
6. 6. Подзолков В.И., Брагина А.Е., Осадчий К.К. и др. Эктопическое ожирение у пациентов без клинически значимых сердечно-сосудистых заболеваний: ориентировочные нормативы, частота и клинические характеристики // Терапевтический архив. 2022. Т. 94. № 9. С. 1072–1077. https://doi.org/10.26442/00403660.2022.09.201847. – EDN JJMRAU.
7. 7. Achari A.E., Jain S.K. Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction // Int. J. Mol. Sci. 2017. V. 18. № 6. Р. 1321. https://doi.org/10.3390/ijms18061321
8. 8. Aghamohammadzadeh R., Greenstein A.S., Yadav R. et al. Effects of bariatric surgery on human small artery function: Evidence for reduction in perivascular adipocyte inf lammation, and the restoration of normal anticontractile activity despite persistent obesity // J. Am. Coll.Cardiol. 2013. V. 62. № 2. P. 128–135. https://doi.org/10.1016/j.jacc.2013.04.027
9. 9. Akcabag E., Bayram Z., Kucukcetin I.O. et al. Functional effects of visfatin in isolated rat mesenteric small resistance arteries // Eur. J. Pharmacol. 2021. V. 908. P. 174333 https://doi.org/10.1016/j.ejphar.2021.174333
10. 10. Akoumianakis I., Antoniades C. The interplay between adipose tissue and the cardiovascular system: Is fat always bad? // Cardiovasc. Res. 2017. V. 113. № 9. P. 999–1008. https://doi.org/10.1093/cvr/cvx111.
11. 11. Antoniades C., Tousoulis D., Vavlukis M. et al. Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers // European heart journal. 2023. V. 44. № 38. P. 3827–3844. https://doi.org/10.1093/eurheartj/ehad484
12. 12. Antonopoulos A.S., Sanna F., Sabharwal N. et al. Detecting human coronary inflammation by imaging perivascular fat // Sci. Transl. Med. 2017. V. 9. № 398. P. eaal2658. https://doi.org/10.1126/scitranslmed.aal2658
13. 13. Atawia R.T., Faulkner J.L., Mehta V. et al. Endothelial leptin receptor is dispensable for leptin-induced sympatho-activation and hypertension in male mice // Vascul. Pharmacol. 2022. V. 146. P. 107093. https://doi.org/10.1016/j.vph.2022.107093.
14. 14. Banerjee R., Chiku T., Kabil O. et al. Assay methods for H2S biogenesis and catabolism enzymes // Methods Enzymol. 2015. V. 554. P. 189–200. https://doi.org/10.1016/bs.mie.2014.11.016
15. 15. Barp C.G., Bonaventura D., Assreuy J. NO, ROS, RAS, and PVAT: More Than a Soup of Letters // Front. Physiol. 2021. V. 12. P. 640021. https://doi.org/10.3389/fphys.2021.640021
16. 16. Bartness T.J., Vaughan C.H., Song C.K. Sympathetic and sensory innervation of brown adipose tissue // Int. J. Obes. (Lond). 2010. V. 34. Suppl 1(01). P. S36–42. https://doi.org/10.1038/ijo.2010.182.
17. 17. Baylie R., Ahmed M., Bonev A.D. et al. Lack of direct effect of adiponectin on vascular smooth muscle cell BKCa channels or Ca2+ signaling in the regulation of small artery pressure-induced constriction // Physiol. Rep. 2017. V. 5. № 16. P. e13337. https://doi.org/10.14814/phy2.13337
18. 18. Bayram Z., Akcabag E., Ozbey G. et al. The Functional Effects of Visfatin on Human Left Internal Mammary Artery // J. Cardiovasc. Pharmacol. 2022. № 80. № 5. P. 725–731. https://doi.org/10.1097/FJC.0000000000001327.
19. 19. Bharadwaj L.A., Prasad K. Mechanism of superoxide anion-induced modulation of vascular tone // Int. J. Angiol. 2002. V. 11. P. 23–29. https://doi.org/10.1007/s00547-001-0049-5.
20. 20. Blüher M. Metabolically Healthy Obesity // Endocr. Rev. 2020. V. 41. № 3. P. bnaa004. https://doi.org/10.1210/endrev/bnaa004
21. 21. Bolić B., Mijušković A., Popović-Bijelić A. et al. Reactions of superoxide dismutases with HS(-)/H2S and superoxide radical anion: An in vitro EPR study // Nitric Oxide. 2015. V. 51. P. 19–23. https://doi.org/10.1016/j.niox.2015.09.008
22. 22. Brown N.K., Zhou Z., Zhang J. et al. Perivascular adipose tissue in vascular function and disease: Areview of current research and animal models // Arterioscler. Thromb. Vasc. Biol. 2014. V. 34. № 8. P. 1621–30. https://doi.org/10.1161/ATVBAHA.114.303029
23. 23. Burgoyne J.R., Madhani M., Cuello F. et al. Cysteine redox sensor in PKGIa enables oxidantinduced activation // Science. 2007. V. 317. № 5843. P. 1393–1397. https://doi.org/10.1126/science.1144318
24. 24. Bussey C.E., Withers S.B., Saxton S.N. et al. β3-Adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived NO and vascular relaxation in small arteries // Br. J. Pharmacol. 2018. V. 175. № 18. P. 3685–3698. https://doi.org/10.1111/bph.14433
25. 25. Cacanyiova S., Golas S., Zemancikova A. et al. The Vasoactive Role of Perivascular Adipose Tissue and the Sulfide Signaling Pathway in a Nonobese Model of Metabolic Syndrome // Biomolecules. 2021. V. 11. № 1. P. 108. https://doi.org/10.3390/biom11010108
26. 26. Ceron C.S., Luizon M.R., Palei A.C. The Potential Role of Visfatin in Mediating Vascular Dysfunction and Hypertension // J. Cardiovasc. Pharmacol. 2023. V. 82. № 5. Р. 347–349. https://doi.org/10.1097/FJC.0000000000001457
27. 27. Chait A., den Hartigh L.J. Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease // Front. Cardiovasc. Med. 2020. V. 7. Р. 22. https://doi.org/10.3389/fcvm.2020.00022
28. 28. Chang L., Villacorta L., Li R. et al. Loss of perivascular adipose tissue on peroxisome proliferator-activated receptor-γ deletion in smooth muscle cells impairs intravascular thermoregulation and enhances atherosclerosis // Circulation. 2012. V. 126. № 9. Р. 1067–1078. https://doi.org/10.1161/ CIRCULATIONAHA.112.104489
29. 29. Chang Y.H., Chang D.M., Lin K.C. et al. Visfatin in overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: A meta-analysis and systemic review // Diabetes/metabolism research and reviews. 2011. V. 27. № 6. Р. 515–527. https://doi.org/10.1002/dmrr.1201
30. 30. Chatterjee T.K., Stoll L.L., Denning G.M. et al. Proinf lammatory phenotype of perivascular adipocytes: Inf luence of high-fat feeding // Circulation research. 2009. V. 104. № 4. Р. 541–549. https://doi.org/10.1161/ CIRCRESAHA.108.182998.
31. 31. Chen H.H., Tseng Y.J., Wang S.Y. et al. The metabolome profiling and pathway analysis in metabolic healthy and abnormal obesity // Int. J. Obes. (Lond). 2015. V. 39. № 8. Р. 1241–1248. https://doi.org/10.1038/ijo.2015.65
32. 32. Cheng C.K., Bakar H.A., Gollasch M., Huang Y. Perivascular adipose tissue: The sixth man of the cardiovascular system // Cardiovasc. Drugs Ther. 2018. V. 32. Р. 481–502. https://doi.org/10.1007/S10557-018-6820-Z
33. 33. Cinti S. The adipose organ // Prostaglandins Leukot. Essent. Fatty Acids. 2005. V. 73. № 1. Р. 9–15. https://doi.org/10.1016/j.plefa.2005.04.010
34. 34. Contreras G.A., Thelen K., Ayala-Lopez N., Watts S.W. The distribution and adipogenic potential of perivascular adipose tissue adipocyte progenitors is dependent on sexual dimorphism and vessel location // Physiological reports. 2016. V. 4. № 19. Р. e12993. https://doi.org/10.14814/phy2.12993
35. 35. Costa R.M., Filgueira F.P., Tostes R.C. et al. H2O2 generated from mitochondrial electron transport chain in thoracic perivascular adipose tissue is crucial for modulation of vascular smooth muscle contraction // Vascul. Pharmacol. 2016. V. 84. Р. 28–37. https://doi.org/10.1016/j.vph.2016.05.008.
36. 36. Denizalti M., Bozkurt T.E., Akpulat U. et al. The vasorelaxant effect of hydrogen sulfide is enhanced in streptozotocin-induced diabetic rats // Naunyn Schmiedebergs Arch. Pharmacol. 2011. V. 383. № 5. Р. 509–517. https://doi.org/10.1007/s00210-011-0601-6
37. 37. Dessie G., Ayelign B., Akalu Y., Shibabaw T., MollaM.D. Effect of Leptin on Chronic Inflammatory Disorders: Insights to Therapeutic Target to Prevent Further Cardiovascular Complication // Diabetes, metabolic syndrome and obesity: targets and therapy. 2021. V. 14. Р. 3307–3322. https://doi.org/10.2147/DMSO.S321311
38. 38. Dos Reis Costa D.E.F., Silveira A.L.M., Campos G.P. et al. High-Carbohydrate Diet Enhanced the Anticontractile Effect of Perivascular Adipose Tissue Through Activation of Renin-Angiotensin System // Front. Physiol. 2021. V. 11. Р. 628101. https://doi.org/10.3389/fphys.2020.628101.
39. 39. Efremova A., Senzacqua M., Venema W. et al. A large proportion of mediastinal and perirenal visceral fat of Siberian adult people is formed by UCP1 immunoreactive multilocular and paucilocular adipocytes // J. Physiol. Biochem. 2020. V. 76. № 2. Р. 185–192. https://doi.org/10.1007/s13105-019-00721-4.
40. 40. Emont M.P., Jacobs C., Essene A.L. et al. A singlecell atlas of human and mouse white adipose tissue // Nature. 2022. V. 603. № 7903. Р. 926–933. https://doi.org/10.1038/s41586-022-04518-2
41. 41. Fang L., Zhao J., Chen Y. et al. Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator // J. Hypertens. 2009. V. 27. № 11. Р. 2174–2185. https://doi.org/10.1097/HJH.0b013e328330a900
42. 42. Farr O.M., Gavrieli A., Mantzoros C.S. Leptin applications in 2015: what have we learned about leptin and obesity? // Curr. Opin. Endocrinol. Diabetes Obes. 2015. V. 22. № 5. Р. 353–359. https://doi.org/10.1097/ MED.0000000000000184.
43. 43. Fésüs G., Dubrovska G., Gorzelniak K. et al. Adiponectin is a novel humoral vasodilator // Cardiovasc Res. 2007. V. 75. № 4. Р. 719–727. https://doi.org/10.1016/j.cardiores.2007.05.025
44. 44. Formentini L., Moroni F., Chiarugi A. Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo // Biochem. Pharmacol. 2009. V. 77. Р. 1612–1620. https://doi.org/10.1016/j.bcp.2009.02.017
45. 45. Fortuño A., Rodríguez A., Gómez-Ambrosi J. et al. Leptin inhibits angiotensin II-induced intracellular calcium increase and vasoconstriction in the rat aorta // Endocrinology. 2002. V. 143. № 9. Р. 3555–3560. https://doi.org/10.1210/en.2002-220075.
46. 46. Furukawa S., Fujita T., Shimabukuro M. et al. Increased oxidative stress in obesity and its impact on metabolic syndrome // The Journal of clinical investigation. 2004. V. 114. № 12. Р. 1752–1761. https://doi.org/10.1172/JCI21625.
47. 47. Gálvez-Prieto B., Bolbrinker J., Stucchi P. et al. Comparative expression analysis of the reninangiotensin system components between white and brown perivascular adipose tissue // J. Endocrinol. 2008. V. 197. № 1. Р. 55–64. https://doi.org/10.1677/JOE-07-0284
48. 48. Gao Y.J., Lu C., Su L.Y. et al. Modulation of vascular function by perivascular adipose tissue: The role of endothelium and hydrogen peroxide // Br. J. Pharmacol. 2007. V. 151. Р. 323–331. https://doi.org/10.1038/sj.bjp.0707228.
49. 49. Gao Y.J., Takemori K., Su L.Y. et al. Perivascular adipose tissue promotes vasoconstriction: the role of superoxide anion // Cardiovasc. Res. 2006. V. 71. № 2. Р. 363–373. https://doi.org/10.1016/j.cardiores.2006.03.013.
50. 50. Gil-Ortega M., Somoza B., Huang Y. et al. Regional differences in perivascular adipose tissue impacting vascular homeostasis // Trends in Endocr. Metab. 2015. V. 26. № 7. Р. 367–375. https://doi.org/10.1016/j.tem.2015.04.003.
51. 51. Giordano A., Smorlesi A., Frontini A. et al. White, brown and pink adipocytes: The extraordinary plasticity of the adipose organ // Eur. J. Endocrinol. 2014. V. 170. № 5. Р. R159–R171. https://doi.org/10.1530/EJE-13-0945
52. 52. Gomart S., Gaudreau-Ménard C., Jespers P. et al. Leptin-Induced Endothelium-Independent Vasoconstriction in Thoracic Aorta and Pulmonary Artery of Spontaneously Hypertensive Rats: Role of Calcium Channels and Stores // PLoS One. 2017. V. 12. № 1. Р. e0169205. https://doi.org/10.1371/journal.pone.0169205.
53. 53. Gossl M., Herrmann J., Tang H. et al. Prevention of vasa vasorumneovascularization attenuates early neointima formation in experimental hypercholesterolemia // Basic Res. Cardiol. 2009. V. 104. № 6. Р. 695–706. https://doi.org/10.1007/s00395-009-0036-0
54. 54. Hajer G.R., van Haeften T.W., Visseren F.L. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases // Eur. Heart J. 2008. V. 29. № 24. Р. 2959–2971. https://doi.org/10.1093/eurheartj/ehn387
55. 55. Hillock-Watling C., Gotlieb A.I. The pathobiology of perivascular adipose tissue (PVAT), the fourth layer of the blood vessel wall // Cardiovasc. Pathol. 2022. V. 61. Р. 107459. https://doi.org/10.1016/j.carpath.2022.107459
56. 56. Huang Y., Tang C., Du J., Jin H. Endogenous Sulfur Dioxide: A New Member of Gasotransmitter Family in the Cardiovascular System // Oxid. Med. Cell Longev. 2016. V. 2016. Р. 8961951. https://doi.org/10.1155/2016/8961951.
57. 57. Jamroz-Wiśniewska A., Gertler A., Solomon G. et al. Leptin-induced endothelium-dependent vasorelaxation of peripheral arteries in lean and obese rats: role of nitric oxide and hydrogen sulfide // PLoS One. 2014. V. 9. № 1. Р. e86744. https://doi.org/10.1371/journal.pone.0086744
58. 58. Kida M., Sugiyama T., Yoshimoto T., Ogawa Y. Hydrogen sulfide increases nitric oxide production with calcium-dependent activation of endothelial nitric oxide synthase in endothelial cells // Eur. J. Pharm. Sci. 2013. V. 48. № 1–2. Р. 211–215. https://doi.org/10.1016/j.ejps.2012.11.001.
59. 59. Klüner L.V., Oikonomou E.K., Antoniades C. Assessing Cardiovascular Risk by Using the Fat Attenuation Index in Coronary CT Angiography // Radiol. Cardiothorac. Imaging. 2021. V. 3. № 1. Р. e200563. https://doi.org/10.1148/ryct.2021200563
60. 60. Knock G.A., Snetkov V.A., Shaifta Y. et al. Superoxide constricts rat pulmonary arteries via Rho-kinase-mediated Ca(2+) sensitization // Free Radic. Biol. Med. 2009. V. 46. № 5. Р. 633–642. https://doi.org/10.1016/j.freeradbiomed
61. 61. Koenen M., Hill M.A., Cohen P., Sowers J.R. Obesity, Adipose Tissue and Vascular Dysfunction // Circ. Res. 2021. V. 128. № 7. Р. 951–968. https://doi.org/10.1161/ CIRCRESAHA.121.318093
62. 62. Kuji I., Imabayashi E., Minagawa A. et al. Brown adipose tissue demonstrating intense FDG uptake in a patient with mediastinal pheochromocytoma // Ann. Nucl. Med. 2008. V. 22. № 3. Р. 231–235. https://doi.org/10.1007/s12149-007-0096-x
63. 63. Kwok K.H., Lam K.S., Xu A. Heterogeneity of white adipose tissue: molecular basis and clinical implications // Exp. Mol. Med. 2016. V. 48. № 3. Р. e215. https://doi.org/10.1038/emm.2016.5
64. 64. Landsberg L., Aronne L.J., Beilin L.J. et al. Obesity-related hypertension: Pathogenesis, cardiovascular risk, and treatment: a position paper of the The Obesity Society and The American Society of Hypertension // Obesity (Silver Spring). 2013. V. 21. № 1. Р. 8–24. https://doi.org/10.1002/oby.20181.
65. 65. Lázaro-Suárez M.L., Domínguez de la Mora I., Rodríguez-Aguilar J.C. et al. Role of Perivascular Adipose Tissue in Aorta Reactivity from Obese and Hyperglycemic CD-1 Mice: New Insights into Perivascular Adipose Tissue // Metabolic syndrome and related disorders. 2023. V. 21. № 2. Р. 101–108. https://doi.org/10.1089/met.2022.0050
66. 66. Lee H.Y., Despres J.P., Koh K.K. Perivascular adipose tissue in the pathogenesis of cardiovascular disease // Atherosclerosis. 2013. V. 230. № 2. Р. 177–84. https://doi.org/10.1016/j. atherosclerosis.2013.07.037
67. 67. Lee Y.C., Chang H.H., Chiang C.L. et al. Role of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis of hypertension // Circulation. 2011. V. 124. № 10. Р. 1160–1171. https://doi.org/10.1161/ CIRCULATIONAHA.111.027375
68. 68. Lee Y.C., Chang H.H., Liu C.H. et al. Methyl palmitate: A potent vasodilator released in the retina // Invest. Ophthalmol. Vis. Sci. 2010. V. 51. № 9. Р. 4746–4753. https://doi.org/10.1167/iovs.09-5132
69. 69. Lenz M., Arts I.C.W., Peeters R.L.M. et al. Adipose tissue in health and disease through the lens of its building blocks // Sci. Rep. 2020. V. 10. № 1. Р. 10433. https://doi.org/10.1038/s41598-020-67177-1
70. 70. Liu C.H., Hsu H.J., Tseng T.L. et al. COMTCatalyzed Palmitic Acid Methyl Ester Biosynthesis in Perivascular Adipose Tissue and its Potential Role Against Hypertension // J. Pharmacol. Exp. Ther. 2020. V. 373. № 2. Р. 175–183. https://doi.org/10.1124/jpet.119.263517.
71. 71. Löhn M., Dubrovska G., Lauterbach B. et al. Periadventitial fat releases a vascular relaxing factor // FASEB J. 2002. V. 16. № 9. Р. 1057–1063. https://doi.org/10.1096/fj.02-0024com
72. 72. Lu Z., Jiang Z., Tang J. et al. Functions and origins of cardiac fat // FEBS J. 2023. V. 290. № 7. Р. 1705–1718. https://doi.org/10.1111/febs.16388
73. 73. Lu C., Su L.Y., Lee R.M., Gao Y.J. Mechanisms for perivascular adipose tissue-mediated potentiation of vascular contraction to perivascular neuronal stimulation: The role of adipocyte-derived angiotensin II // Eur. J. Pharmacol. 2010. V. 634. № 1–3. Р. 107–112. https://doi.org/10.1016/j.ejphar.2010.02.006.
74. 74. Man A.W.C., Zhou Y., Xia N., Li H. Endothelial Nitric Oxide Synthase in the Perivascular Adipose Tissue // Biomedicines. 2022. V. 10. Р. 1754. https://doi.org/10.3390/biomedicines10071754
75. 75. Maniyadath B., Zhang Q., Gupta R.K., Mandrup S. Adipose tissue at single-cell resolution // Cell metabolism. 2023. V. 35. № 3. Р. 386–413. https://doi.org/10.1016/j.cmet.2023.02.002
76. 76. Mather K.J., Funahashi T., Matsuzawa Y. et al. Adiponectin, change in adiponectin, and progression to diabetes in the Diabetes Prevention Program // Diabetes. 2008. V. 57. № 4. Р. 980–986. https://doi.org/10.2337/db07-1419
77. 77. Mellott E., Faulkner J.L. Mechanisms of leptininduced endothelial dysfunction // Curr. Opin. Nephrol. Hypertens. 2023. V. 32. № 2. Р. 118–123. https://doi.org/10.1097/ MNH.0000000000000867
78. 78. Mendizabal Y., Llorens S., Nava E. Vasoactive effects of prostaglandins from the perivascular fat of mesenteric resistance arteries in WKY and SHROB rats // Life Sci. 2013. V. 93. Р. 1023–1032. https://doi.org/10.1016/j.lfs.2013.10.021.
79. 79. Mughal A., O'Rourke S.T. Vascular effects of apelin: Mechanisms and therapeutic potential // Pharmacol. Ther. 2018. V. 190. Р. 139–147. https://doi.org/10.1016/j.pharmthera.2018.05.013
80. 80. Mustafa A.K., Sikka G., Gazi S.K. et al. Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels // Circ. Res. 2011. V. 109. № 11. Р. 1259–1268. https://doi.org/10.1161/ CIRCRESAHA.111.240242.
81. 81. Neeland I.J., Ross R., Després J.P. et al. Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: A position statement // The lancet. Diabetes Еndocrinol. 2019. V. 7. № 9. Р. 715–725. https://doi.org/10.1016/S2213-8587 (19)30084-1
82. 82. Neves K.B., Lobato N.S., Lopes R.A. et al. Chemerin reduces vascular nitric oxide / cGMP signalling in rat aorta: A link to vascular dysfunction in obesity? // Clinical science. 2014. V. 127. № 2. Р. 111–122. https://doi.org/10.1042/CS20130286.
83. 83. Nóbrega N., Araújo N.F., Reis D. et al. Hydrogen peroxide and nitric oxide induce anticontractile effect of perivascular adipose tissue via renin angiotensin system activation // Nitric Oxide. 2019. V. 84. Р. 50–59. https://doi.org/10.1016/j.niox.2018.12.011
84. 84. Obradovic M., Sudar-Milovanovic E., Soskic S. et al. Leptin and Obesity: Role and Clinical Implication // Front. Endocrinol. 2021. V. 12. Р. 585887. https://doi.org/10.3389/fendo.2021.585887.
85. 85. Oelkrug R., Polymeropoulos E.T., Jastroch M. Brown adipose tissue: Physiological function and evolutionary significance // J. Comp. Physiol B. 2015. V. 185. № 6. Р. 587–606. https://doi.org/10.1007/s00360-015-0907-7.
86. 86. Ohashi K., Shibata R., Murohara T., Ouchi N. Role of anti-inflammatory adipokines in obesity-related diseases // TEM. 2014. V. 25. № 7. Р. 348–355. https://doi.org/10.1016/j.tem.2014.03.009
87. 87. Oikonomou E.K., Marwan M., Desai M.Y. et al. Non-invasive detection of coronary inf lammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): A post-hoc analysis of prospective outcome data // Lancet. 2018. V. 392. № 10151. Р. 929–939. https://doi.org/10.1016/S0140-6736 (18)31114-0
88. 88. Padilla J., Jenkins N.T., Vieira-Potter V.J., Laughlin M.H. Divergent phenotype of rat thoracic and abdominal perivascular adipose tissues // Am. J. Рhysiol. Reg. Integr. Comp. Physiol. 2013. V. 304. № 7. Р. R543–R552. https://doi.org/10.1152/ajpregu.00567.2012.
89. 89. Pan X., Kaminga A.C., Wen S.W., Acheampong K., Liu A. Omentin-1 in diabetes mellitus: A systematic review and meta-analysis // PloS one. 2019. V. 14. № 12. Р. e0226292. https://doi.org/10.1371/journal.pone.0226292
90. 90. Phillips S.A., Somberg L.B., Hatoum O.A., Gutterman D.D. Mechanisms of hydrogen peroxide induced vasoconstriction in human adipose resistance arteries // FASEB J. 2007. V. 21. Р. A491. https://doi.org/10.1096/fasebj.21.5.A491-c.
91. 91. Police S.B., Thatcher S.E., Charnigo R. et al. Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation // Arterioscl. Thromb. Vasc. Biol. 2009. V. 29. № 10. Р. 1458–1464. https://doi.org/10.1161/ATVBAHA.109.192658
92. 92. Rahmouni K. Obesity-associated hypertension: Recent progress in deciphering the pathogenesis // Hypertension. 2014. V. 64. № 2. Р. 215–221. https://doi.org/10.1161/ HYPERTENSIONAHA.114.00920.
93. 93. Reilly S.M., Saltiel A.R. Adapting to obesity with adipose tissue inflammation // Nat. Rev. Endocrinol. 2017. V. 13. Р. 633–643. https://doi.org/10.1038/nrendo.2017.90.
94. 94. Rikitake Y. The apelin/APJ system in the regulation of vascular tone: friend or foe? // J. Вiochem. 2021. V. 169. № 4. Р. 383–386. https://doi.org/10.1093/jb/mvaa129
95. 95. Romacho T., Valencia I., Ramos-González M. et al. Visfatin/eNampt induces endothelial dysfunction in vivo: A role for Toll-Like Receptor 4 and NLRP3 inflammasome // Sci. Rep. 2020. V. 10. Р. 5386. https://doi.org/10.1038/s41598-020-62190-w
96. 96. Sahin A.S., Bariskaner H. The mechanisms of vasorelaxant effect of leptin on isolated rabbit aorta // Fundam. Clin. Pharmacol. 2007. V. 21. № 6. Р. 595–600. https://doi.org/10.1111/j.1472-8206.2007.00541.x
97. 97. Sahin A.S., Bariskaner H., Gökbel H., Okudan N. The dual effects of leptin on aortic rings with and without endothelium isolated from streptozotocin-induced diabetic rats // Methods Find. Exp. Clin. Pharmacol. 2009. V. 31. № 5. Р. 325–329. https://doi.org/10.1358/mf.2009.31.5.1380464.
98. 98. Saito T., Kurazumi H., Suzuki R. et al. Perivascular Adipose Tissue Is a Major Source of Nitric Oxide in Saphenous Vein Grafts Harvested via the NoTouch Technique // J. Am. Hear. Assoc. 2022. V. 11. Р. e020637. https://doi.org/10.1161/JAHA.120.020637.
99. 99. Saito M., Okamatsu-Ogura Y., Matsushita M. et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity // Diabetes. 2009. V. 58. № 7. Р. 1526–1531. https://doi.org/10.2337/db09-0530.
100. 100. Santiago E., Climent B., Muñoz M. et al. Hydrogen peroxide activates store-operated Ca(2+) entry in coronary arteries // Br. J. Рharmacol. 2015. V. 172. № 22. Р. 5318–5332. https://doi.org/10.1111/bph.13322.
101. 101. Santos R.A., Ferreira A.J., Pinheiro S.V. et al. Angiotensin-(1-7) and its receptor as a potential targets for new cardiovascular drugs // Expert. Opin. Investig. Drugs. 2005. V. 14. № 8. Р. 1019–1031. https://doi.org/10.1517/13543784.14.8.1019
102. 102. Santos R.A., Sampaio W.O., Alzamora A.C. et al. The ACE2/Angiotensin-(1-7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1-7) // Physiol. Rev. 2018. V. 98. № 1. Р. 505–553. https://doi.org/10.1152/physrev.00023.2016
103. 103. Schleifenbaum J., Köhn C., Voblova N. et al. Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide // J. Hypertens. 2010. V. 28. № 9. Р. 1875–1882. https://doi.org/10.1097/ HJH.0b013e32833c20d5
104. 104. Schroeter M.R., Eschholz N., Herzberg S. et al. Leptin-dependent and leptin-independent paracrine effects of perivascular adipose tissue on neointima formation // Arterioscler. Thromb. Vasc. Biol. 2013. V. 33. № 5. Р. 980–987. https://doi.org/10.1161/ATVBAHA.113.301393
105. 105. Sena C.M., Pereira A., Fernandes R. et al. Adiponectin improves endothelial function in mesenteric arteries of rats fed a high-fat diet: Role of perivascular adipose tissue // Br. J. Pharmacol. 2017. V. 174. № 20. Р. 3514–3526. https://doi.org/10.1111/bph.13756
106. 106. Shabalina I.G., Ost M., Petrovic N. et al. Uncoupling protein-1 is not leaky // Biochim. Biophys. Acta. 2010. V. 1797. Р. 773–784. https://doi.org/10.1016/j.bbabio.2010.04.007
107. 107. Small H.Y., McNeilly S., Mary S. et al. Resistin Mediates Sex-Dependent Effects of Perivascular Adipose Tissue on Vascular Function in the Shrsp // Scientific reports. 2019. V. 9. № 1. Р. 6897. https://doi.org/10.1038/s41598-019-43326-z
108. 108. Soltis E.E., Cassis L.A. Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness // Clin. Exp. Hypertens. A. 1991. V. 13. № 2. Р. 277–296. https://doi.org/10.3109/10641969109042063
109. 109. Stanek E., Czamara K. Imaging of perivascular adipose tissue in cardiometabolic diseases by Raman spectroscopy: Towards single-cell analysis // Biochim. Biophys. Acta Mol. Cell. Biol. Lipids. 2024. V. 1869. № 5. Р. 159484. https://doi.org/10.1016/j.bbalip.2024.159484.
110. 110. Stastny J., Bienertova-Vasku J., Vasku A. Visfatin and its role in obesity development // Diabetes Metab. Syndr. 2012. V. 6. № 2. Р. 120–124. https://doi.org/10.1016/j.dsx.2012.08.011
111. 111. Sun C., Yu W., Lv B. et al. Role of hydrogen sulfide in sulfur dioxide production and vascular regulation // PloS One. 2022. V. 17. № 3. Р. e0264891. https://doi.org/10.1371/journal.pone.0264891
112. 112. Szasz T., Webb R.C. (2012) Perivascular adipose tissue: More than just structural support // Clin. Sci. V. 122. № 1. Р. 1–12. https://doi.org/10.1042/CS20110151
113. 113. Van Dam A.D., Boon M.R., Berbée J.F.P. et al. Targeting white, brown and perivascular adipose tissue in atherosclerosis development // Eur. J. Pharmacol. 2017. V. 816. Р. 82–92. https://doi.org/10.1016/j.ejphar.2017.03.051
114. 114. Van Gaal L.F., Mertens I.L., De Block C.E. Mechanisms linking obesity with cardiovascular disease // Nature. 2006. V. 444. № 7121. Р. 875–880. https://doi.org/10.1038/nature05487
115. 115. Victorio J.A., Davel A.P. Perivascular Adipose Tissue Oxidative Stress on the Pathophysiology of Cardiometabolic Diseases // Curr. Hypertens. Rev. 2020. V. 16. № 3. Р. 192–200. https://doi.org/10.2174/15734021156661904101 53634
116. 116. Victorio J.A., Fontes M.T., Rossoni L.V., Davel A.P. Different Anti-Contractile Function and Nitric Oxide Production of Thoracic and Abdominal Perivascular Adipose Tissues // Frontiers in physiology. 2016. V. 7. Р. 295. https://doi.org/10.3389/fphys.2016.00295
117. 117. Villarroya F., Cereijo R., Villarroya J., Giralt M. Brown adipose tissue as a secretory organ // Nat Rev Endocrinol. 2017. V. 13. № 1. Р. 26–35. https://doi.org/10.1038/nrendo.2016.136.
118. 118. Wabel E.A., Krieger-Burke T., Watts S.W. Vascular chemerin from PVAT contributes to norepinephrine and serotonin-induced vasoconstriction and vascular stiffness in a sexdependent manner // Am. J. Physiol. 2024. V. 327. № 6. P. H1577–H1589. https://doi.org/10.1152/ajpheart.00475.2024
119. 119. Wang J., Gao Y., Lin F. et al. Omentin-1 attenuates lipopolysaccharide (LPS)-induced U937 macrophages activation by inhibiting the TLR4/MyD88/NF-κB signaling // Arch. Вiochem. Вiophys. 2020. V. 679. Р. 108187. https://doi.org/10.1016/j.abb.2019.108187
120. 120. Wang N., Kuczmanski A., Dubrovska G., Gollasch M. Palmitic Acid Methyl Ester and Its Relation to Control of Tone of Human Visceral Arteries and Rat Aortas by Perivascular Adipose Tissue // Front. Physiol. 2018. V. 9. Р. 583. https://doi.org/10.3389/fphys.2018.00583
121. 121. Wang P., Xu T.Y., Guan Y.F. et al. Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide // Cardiovasc. Res. 2009. V. 81. № 2. Р. 370–380. https://doi.org/10.1093/cvr/cvn288
122. 122. Weston A.H., Egner I., Dong Y. et al. Stimulated release of a hyperpolarizing factor (ADHF) from mesenteric artery perivascular adipose tissue: Involvement of myocyte BKCa channels and adiponectin // Br. J. Pharmacol. 2013. V. 169. № 7. Р. 1500–1509. https://doi.org/10.1111/bph.12157
123. 123. Withers S.B., Bussey C.E., Saxton S.N. et al. Mechanisms of adiponectin-associated perivascular function in vascular disease // Arterioscler. Thromb. Vasc. Biol. 2014. V. 34. № 8. Р. 1637–1642. https://doi.org/10.1038/srep4457110.1161/ ATVBAHA.114.303031
124. 124. Withers S.B., Forman R., Meza-Perez S. et al. Eosinophils are key regulators of perivascular adipose tissue and vascular functionality // Scientific reports. 2017. V. 7. Р. 44571. https://doi.org/10.1038/srep44571
125. 125. Xia N., Horke S., Habermeier A. et al. Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of DietInduced Obese Mice // Arterioscler. Thromb. Vasc. Biol. 2016. V. 36. № 1. Р. 78–85. https://doi.org/10.1161/ATVBAHA.115.306263
126. 126. Xia N., Li H. The role of perivascular adipose tissue in obesity-induced vascular dysfunction // Br. J. Pharmacol. 2017. V. 174. № 20. Р. 3425–3442. https://doi.org/10.1111/bph.13650.
127. 127. Yamawaki H., Hara N., Okada M., Hara Y. Visfatin causes endothelium-dependent relaxation in isolated blood vessels // Biochem. Biophys. Res. Commun. 2009. V. 383. № 4. Р. 503–508. https://doi.org/10.1016/j.bbrc.2009.04.074
128. 128. Yamawaki H., Tsubaki N., Mukohda M. et al. Omentin, a novel adipokine, induces vasodilation in rat isolated blood vessels // Biochem. Biophys. Res. Comm. 2010. V. 393. № 4. Р. 668–672. https://doi.org/10.1016/j.bbrc.2010.02.053
129. 129. Yang T., Du Y. Distinct roles of central and peripheral prostaglandin E2 and EP subtypes in blood pressure regulation // Am. J. Hypertens. 2012. V. 25. Р. 1042–1049. https://doi.org/10.1038/ajh.2012.67.
130. 130. Yao Q., Huang Y., Liu A.D. et al. The vasodilatory effect of sulfur dioxide via SGC/ cGMP/PKG pathway in association with sulfhydryl-dependent dimerization. //Am. J. Physiol. Regul. Integr. Comp. Physiol. 2016. V. 310. № 11. Р. R1073-80. https://doi.org/10.1152/ajpregu.00101.2015
131. 131. Yudkin J.S., Eringa E., Stehouwer C.D. ‘Vasocrine’ signalling from perivascular fat: Amechanism linking insulin resistance to vascular disease // Lancet. 2005. V. 365. Р. 1817–1820. https://doi.org/10.1016/S0140-6736 (05)66585-3
132. 132. Zamanian M.Y., Maleki S., Oghenemaro E.F. et al. Omentin-1 as a promising biomarker and therapeutic target in hypertension and heart failure: A comprehensive review // Naun.Schm. Arch. Pharmacol. 2025. 10.1007/s00210025-04008-y. https://doi.org/10.1007/s00210-025-04008-y
133. 133. Zhang H., Huang Y., Bu D. et al. Endogenous sulfur dioxide is a novel adipocyte-derived inflammatory inhibitor // Sci. Rep. 2016. V. 6. Р. 27026. https://doi.org/10.1038/srep27026
134. 134. Zhang Y., Proenca R., Maffei M. et al. Positional Cloning of the Mouse Obese Gene and its Human Homologue // Nature. 1994. V. 372. Р. 425–432. https://doi.org/10.1038/372425a0
135. 135. Zhang Y.Y., Shi Y.N., Zhu N. et al. PVAT targets VSMCs to regulate vascular remodelling: Angel or demon // Journal of drug targeting / 2021. V. 29. № 5. Р. 467–475. https://doi.org/10.1080/1061186X.2020.1859515