ОФУспехи физиологических наук Progress in Physiological Science

  • ISSN (Print) 0301-1798
  • ISSN (Online) 3034-6118

Роль LIM-киназы 1 в процессах памяти

Код статьи
10.31857/S0301179823040069-1
DOI
10.31857/S0301179823040069
Тип публикации
Статус публикации
Опубликовано
Авторы
Том/ Выпуск
Том 54 / Номер выпуска 4
Страницы
36-56
Аннотация
Согласно современным представлениям, основу интеллектуальных проблем при нейрологических повреждениях мозга составляет активное забывание, регулируемое зависимыми от малых ГТФаз Rac и Rho сигнальными каскадами ремоделирования актина. Ключевой фермент этих каскадов – LIM-киназа 1 (LIMK1). Изменения экспрессии гена limk1 приводят к нейрокогнитивным патологиям. Для экспресс-скрининга и тестирования агентов целенаправленного терапевтического воздействия, изменяющих белок-белковые взаимодействия ГТФаз и компонентов сигнальных каскадов, необходимо создание и валидация простых животных моделей. Такую возможность предоставляет дрозофила, мутантные линии которой позволяют выявить узловые моменты пересечений биохимических и нервных сетей, сопровождающие активное забывание.
Ключевые слова
<i>:</i> обучение память забывание LIMK1 нейродегенеративные заболевания
Дата публикации
14.09.2025
Год выхода
2025
Всего подписок
0
Всего просмотров
7

Библиография

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